M.D. in Germany, “Houji scholar” distinguished Professor. Director of Library, NWAFU.
Born in Sept.1964, Gaoqing, Shandong, China
Address: College of Veterinary Medicine, Northwest A&F University
No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Mobile: +86 18700975432
1. Education and Work Experience
01.2011 – now, Professor, College of Veterinary Medicine, Northwest A&F University
11.2008 – 03.2012, Professor, College of Life Science, Lanzhou University
10.2004 – 12.2010, Assistant Professor, Medical College, University of Freiburg, Germany
02.2001 – 09.2004, Postdoctoral training, Medical College, University of Freiburg, Germany
10.1998 – 01.2001, M.D., Medical College, University of Freiburg, Germany
07.1988 – 09.1998, Assistant, Lecture and Associate Professor, Xinjiang Medical University
09.1985 – 07.1988, Master, Medicine, Xinjiang Medical University
09.1980 – 07.1985, Bachelor, Medicine, Binzhou Medical College
2. Research and Teaching
Cellular and molecular mechanisms of brain development,
Synaptic plasticity and Learning and Memory,
Adult neural stem cells and Neurogenesis,
Healthy breeding of livestock and poultry,
Nutritional and medicinal value of Acer truncatum Bounge,
Traditional Chinese medicine in the prevention and treatment of neurodegenerative diseases.
Anatomy, Histology and Embryology, Neurobiology for bachelor students.
Advanced Neurobiology, Immunohistochemistry for master students.
Frontiers in Neurobiology for doctoral students.
3. Memberships and Academic Services
Member of Society for Neuroscience USA
Member of Society for Neuroscience of European
Member of Chinese Neuroscience Society
Executive Committee Member of animal welfare and health breeding Society in the Chinese Animal Husbandry and Veterinary Society
Executive Committee Member of Society for animal Anatomy, Histology and Embryology in the Chinese Animal Husbandry and Veterinary Society
Deputy Director of Research Center for Acer truncatum Bunge Engineering Technology of National Forestry and Grass Administration
4. Honors and Awards
Distinguished Professor of "Cuiying Scholar" in Lanzhou University.
Distinguished experts of Shaanxi "Sanqin Scholars" and Sichuan "Tianfu Scholars"
(1) Papers as first author
 Chai X#, Zhao S# (equal contributed), Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz HG, Frotscher M. Reelin and cofilin cooperate during the migration of cortical neurons: A quantitative morphological analysis. Development . 2016 Mar 15;143(6):1029-40. (IF ="5.611)"
 Studer D#, Zhao S# (equal contributed), Chai X, Jonas Peter, Graber W , Nestel S, Frotscher M. Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. Nature Protocols . 2014;9(6):1480-95. (IF="7.950)
 Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M. Structural plasticity of spines at giant mossy fiber synapses. Front Neural Circuits. 2012; 6:103-110. (IF="3.385)
 Zhao S, Studer D, Graber W, Nestel S, Frotscher M. Fine structure of hippocampal mossy fiber synapses following rapid high-pressure freezing. Epilepsia. 2012;53 Suppl 1:4-8. (IF3=".909)
 Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, Saetzler K, Frotscher M. Structural plasticity of hippocampal mossy fiber synapses as revealed by high-pressure freezing. J Comp Neurol. 2012;520(11):2340-51. (IF="3.661)
 Zhao S, Frotscher M. Go or stop? Divergent roles of Reelin in radial neuronal migration. Neuroscientist. 2010; 16(4):421-34. (IF="5.952)
 Zhao S, Chai X, Bock HH, Brunne B, Forster E, Frotscher M. Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1. J Comp Neur ol. 2006; 495(1):1-9. (IF=3.661)
 Zhao S, Chai X, Forster E, Frotscher M. Reelin is a positional signal for the lamination of dentate granule cells. Development. 2004; 131(20):5117-5125. (IF =7.3)
 Zhao S, Forster E, Chai X, Frotscher M. Different signals control laminar specificity of commissural and entorhinal fibers to the dentate gyrus. J Neurosc i . 2003; 23(19):7351-7357. ( IF="7.452)
 Forster E#, Jossin Y#, Zhao S# (equal contributed), Chai X, Frotscher M, Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur J Neurosci. 2006;23(4):901-909. (IF="3.385)
 Zhao S, Chai X, Frotscher M. Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin. Dev Neurosci. 2007;29(1-2):84-90
(2) Papers as corresponding author
 Sun P, Wang M, Li Z, Wei J, Liu F, Zheng W, Zhu X, Chai X, Zhao S*. Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism. Theranostics . 2022 May 1;12(8):3637-3655.
 Xue Y, Zhu X, Yan W, Zhang Z, Cui E, Wu Y, Li C, Pan J, Yan Q, Chai X, Zhao S*. Dietary supplementation with Acer truncatum oil promotes remyelination in a mouse model of Multiple Sclerosis. Front Neurosci. 2022 May 2;16:860280.
 Huang J, Chai X, Wu Y, Hou Y, Li C, Xue Y, Pan J, Zhao Y, Su A, Zhu X, Zhao S*.β-Hydroxybutyric acid attenuates heat stress-induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF-κB pathways in the hippocampus. FASEB J. 2022 Apr;36(4):e22264.
 Li C, Chai X, Pan J, Huang J, Wu Y, Xue Y, Zhou W, Yang J, Zhu X, Zhao S*. β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. J Mol Neurosci. 2022 May;72(5):923 -938.
 Zhu X, Huang J, Wu Y, Zhao S*, Chai X. Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits. Cell Mol Neurobiol. 2021 Nov 12. doi: 10.1007/s10571-021-01165-5. Online ahead of print.
 Zhu X, Wu Y, Pan J, Li C, Huang J, Cui E, Chen Z, Zhou W, Chai X, Zhao S*. Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol. Int J Neuropsychopharmacol . 2021 May 18;24(5):419-433.
 Zhang Q, Liu F, Yan W, Wu Y, Wang M, Wei J, Wang S, Zhu X, Chai X, Zhao S*. Prolonged maternal separation alters neurogenesis and synaptogenesis in postnatal dentate gyrus of mice. Bipolar Disord. 2021 Jun;23(4):376-390.
 Chai X, Zhang W, Li L, Wu Y, Zhu X, Zhao S*. Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth. Front Mol Neurosci. 2020 Aug 12;13:147.
 Zhu X, Wu Y, Li C, Yan W, Pan J, Wang S, Zhao S*. Prenatal Exposure to Gossypol Impairs Corticogenesis of Mouse. Front Neurosci. 2020 Apr 3;14:318. doi: 10.3389/fnins.2020.00318. eCollection 2020.
 Shuzhong Wang, Xuzhao Li, Qianru Zhang, Xuejun Chai, Yi Wang, Eckart Förster, Xiaoyan Zhu*, Shanting Zhao* .Nyap1 Regulates Multipolar–Bipolar Transition and Morphology of Migrating Neurons by Fyn Phosphorylation during Corticogenesis. Cerebral Cortex. 2020,30:929-941. 5.437
 Peng Chen, Maofang Hei, Lili Kong, Yinyin Liu, Yu Yang Haibo Mu, Xiuyun Zhang, Shanting Zhao* and Jinyou Duan* . One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome. Food & Function. 2019,10(12):8161 – 8171， 3.241
 Xiaoyan Zhu*, Yongji Wu, Cixia Li, Wenyong Yan, Jiarong Pan, Shuzhong Wang, Shanting, Zhao*. Prenatal Exposure to Gossypol Impairs Corticogenesis of Mouse. Frontiers in Neuroscience ; 2020,Apr 3,. DOI:10.3389/ fnins. 2020.00318，IF=3.707
 Mengmeng Liu, Mingrui Xu, Mengli Wang, Shuzhong Wang, Kaikai Li, Xinran Cheng, Yongji Wu, Yi Wang, Xiaoyan Zhu*, Shanting Zhao*. Maternal exposure to swainsonine impaired the early postnatal development of mouse dentate gyrus of offspring. Neurochemistry International, 129, 104511， IF="3.881
 Hei M, Chen P, Wang S, Li X, Xu M, Zhu X, Wang Y, Duan J, Huang Y*, Zhao S*. Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus. Behav Brain Res. 2019 Jun 3;365:26-35. doi: 10.1016/j.bbr.2019.02.044. Epub 2019 Feb 27 ，IF=2.77
 Zhuang M, Li B, Huang Y, Lei Q, Yan R, Li N, Sidhu K, Cheng X, Yan X, Miao Y, Zhao S*, Hua J*. Reelin regulates male mouse reproductive capacity via the sertoli cells. J Cell Biochem. 2018 Oct 18. doi: 10.1002/jcb.26824. IF="4.237
 Liu M, Li G, Wang M, Cheng X, Huang Y, Xu M, Li K, Chen J, Zhu X, Zhao S*. Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons. J Mol Histol. 2018 Oct;49(5):519-530.
 Cheng X, Li K, Liu M, Xu M, Hu X, Yan R, Förster E, Zhao S*. The effect of P85 on neuronal proliferation and differentiation during development of mouse cerebral cortex. Dev Biol . 2018 Sep 1;441(1):95-103. IF="2.895
 Liu M, Cheng X, Li K, Xu M, Wu Y, Wang M, Zhang Q, Yan W, Luo C, Zhao S* Process in menstrual blood-derived mesenchymal stem cells for treatment of central nervous system diseases. Sheng Wu Gong Cheng Xue Bao . 2018 May 25;34(5):644-652.
 Cheng X, Li K, Liu M, Hu X, Xu M, Yan R, Zhao S*. P85 regulates neuronal migration through affecting neuronal morphology during mouse corticogenesis. Cell Tissue Res. 2018 Apr;372(1):23-31.
 An L, Li W, Hu X, Zhang W, Zhao S*. Abundant Focal Adhesion Kinase Causes Aberrant Neuronal Migration Via Its Phosphorylation at Tyr925. J Mol Neurosci. 2018 Jan;64(1):102-110.
 Fang J, Wei Y, Teng X, Zhao S*, Hua J*. Immortalization of canine adipose-derived mesenchymal stem cells and their seminiferous tubule transplantation. J Cell Biochem. 2018 Apr;119(4):3663-3670.
 Li X, Xie J, Hei M, Tang J, Wang Y, Förster E, Zhao S*. High level of CTP synthase induces formation of cytoophidia in cortical neurons and impairs corticogenesis. Histochem Cell Biol. 2018 Jan;149(1):61-73.（IF=2.5529）
 Xu M, Huang Y, Li K, Cheng X, Li G, Liu M, Nie Y, Geng S, Zhao S*. Developmental exposure of decabromodiphenyl ether impairs subventricular zone neurogenesis and morphology of granule cells in mouse olfactory bulb. Arch Toxicol . 2018 Jan;92(1):529-539.（IF=5.9010）
 Li K, Cheng X, Jiang J, Wang J, Xie J, Hu X, Huang Y, Song L, Liu M, Cai L, Chen L, Zhao S*. The toxic influence of paraquat on hippocampal neurogenesis in adult mice. Food Chem Toxicol . 2017 Aug;106(Pt A):356-366. （IF=3.7780）
 Huang Y, Li G, An L, Fan Y, Cheng X, Li X, Yin Y, Cong R, Chen S, Zhao S*. Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex. Neuroscience . 2017 Jun 3;352:39-51. （IF=3.2769）
 Xie J, Li X, Zhang W, Chai X, Huang Y, Li K, Cheng X, Zhao S*. Aberrant expression of LIMK1 impairs neuronal migration during neocortex development. Histochem Cell Biol . 2017 Apr;147(4):471-479. （IF=2.5529）
 Chai X, Fan L, Shao H, Lu X, Zhang W, Li J, Wang J, Chen S, Frotscher M, Zhao S *. Reelin Induces Branching of Neurons and Radial Glial Cells during Corticogenesis. Cerebral Cortex . 2015 ;25(10):3640-53（IF=8.109）
 Jiutao Wang, Lingzhen Song, Lingling Li, Wei Zhang, Xuejun Chai, Lei. An, Shulin Chen, Michael Frotscher, Shanting Zhao*. SRC controls neuronal migration by regulating the activity of FAK and cofilin. Neuroscience 2015, 292(1):90–100（IF=3.564）
 Runchuan Yan，Xinde Hu，Wei Zhang，Lingzhen Song，Jiutao Wang，Yupeng Yin，Shulin Chen，Shanting Zhao*. The mouse radial spoke protein 3 is a nucleocytoplasmic shuttling protein that promotes neurogenesis. Histochem Cell Biol, 2015 Oct;144(4):309-19.（IF=3.054）
 Wang J, Song L, Zhang Q, Zhang W, An L, Zhang Y, Tong D, Zhao B, Chen S, Zhao S *. Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory. Toxicology Letters . 2015, 232(1):263–270. (IF=3.355)
 An L, Song L, Zhang W, Lu X, Chen S, Zhao S*. The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis. Exp Cell Res. 2014 Nov 1;328(2):419-28.（IF=3.372）
 Song L, Zhao S, Frotscher M, Chai X. Phosphorylation of Focal Adhesion Kinase at Y925: Role in Glia-Dependent and Independent Migration through Regulating Cofilin and N-Cadherin. Mol Neurobiol. 2022 Jun;59(6):3467-3484.
(3) Paper with highest impact factor:
 Forster E, Zhao S, Frotscher M. Laminating the hippocampus. Nature Reviews Neuroscience. 2006; 7(4):259-267. (IF=36.573)
 R esearch Progress of Acer truncatum and nervonic acid. 1th Edition, Editor-in-Chief, Northwest A&F University Press (2020).
6. Projects and Funding
 Application of Yuanbao maple leaf in healthy breeding of livestock and poultry and development of related products. Talent project of Sichuan Province. No. 2020-120, 200,000 RMB Yuan, 2021.01-2023.12, grant holder.
 Study on the preventive and therapeutic effects of Eucommia on Alzheimer’s disease. Japanese K4030220524, Eucommia ulmoides Research Association assisted project. 1,000,000 JPY Yen, 2020.08-2022.07, grant holder.
 Research and development of key technologies for high-value utilization of Eucommia ulmoides leaf forest resources. Key projects of intergovernmental international scientific and technological innovation cooperation. No. 2018YFE0127000, Ministry of Science and Technology. 350,000 RMB Yuan, 2020.01-2022.12, Sub project leader.
 Research on nutritional and medicinal value of Acer truncatum oil and nervonic acid and development of related products. Key Research & Development projects of Shaanxi Province. No. 2020QFY1004, Natural Science Foundation of Shaanxi Province. 250,000 RMB Yuan, 2020.01-2022.12, Sub project leader.
 Study on Key Technologies of cultivation and efficient utilization of Acer truncatum resources. Key Research & Development projects of Shaanxi Province. No.2018ZDXM2, Natural Science Foundation of Shaanxi Province. 160,000 RMB Yuan, 2019.01-2021.12, Sub project leader.
 Adult neurogenesis of Qinghai sand lizard and the influence of ecological environment on it General Project, No. 31572477, National Natural Science Foundation of China (NSFC), 630,000 RMB Yuan, 2016.01 – 2019.12, grant holder.
 Adult neurogenesis of Qinghai sand lizard and the influence of ecological environment on it. General Project, No. 31071873, National Natural Science Foundation of China (NSFC), 350,000 RMB Yuan, 2011 .01- 2013.12, grant holder.
 Research on Key Technologies of healthy pig breeding based on animal welfare. Key Project, No. 2016KTCL02-19, Natural Science Foundation of Shaanxi Province. 2016.01 – 2017.12, grant holder.