GUO kangkang


Full Name: GUO Kangkang Gender: Male Year of Birth: 1973

Working Address: College of Veterinary Medicine, Northwest A&F University


Phone: +86-29-7092040 Fax: +86-29-7091032


2003.09 - 2010.06, Ph. D., Clinical Veterinary Medicine, Northwest A&F University, China

2008.01 - 2009.01, Visiting Scholar, Department of Pathology & Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Canada

2000.09 - 2004.01, M.D., Preventive Veterinary Medicine, Northwest A&F University, China

1992.09 - 1997.06, B.S., Veterinary Medicine, Northwest Agricultural University, China


From 1997.06 to 2002.11, he worked as a Teaching assistant at Northwest Agricultural University, China. In 2002.12, he started working as Lecturer at Northwest A&F University, China and in 2012.01, he was promoted as Associate Professor. From 2022.01, he became the full-time Professor in the College of Veterinary Medicine, Northwest A&F University, China. His main areas of expertise include Zoonoses Control and Animal Product Safety, Pathogenesis of Viral Infections of Animals, Diagnosis of Viral Infections and Animal Gene Engineering Vaccine. In addition, he also gives lectures including Animal Derived Food Hygiene; Veterinary Science; Veterinary Public Health for Undergraduate students and Veterinary Public Health and Food Safety for Graduate students. He is also a member of the Chinese Association of Cell Biology, a member of the Branch Association of Animal Derived Food Hygiene, and a member of the Chinese Association of Animal Science and Veterinary Medicine. His research has been supported by several (personal) grants including the National Natural Science Foundation of China. He has published many research papers in several prestigious journals and the selected publications are listed below.


1. Liang Zhang#, Tao Wang#, Yanyan Yi#, Mengzhao Song, Mingxing Jin, Kangkang Guo*, Yanming Zhang*, ARF1 with Sec7 domain-dependent 1 GBF1 activates coatomer protein I to support classical swine fever virus entry, Journal of Virology, 2022, 96(6):e02193-21

2. Tao Wang#, Liang Zhang#, Wulong Liang#, Shanchuan Liu, Wen Deng, Yangruiyu Liu, Yaru Liu, Mengzhao Song, Kangkang Guo*, Yanming Zhang*, Extracellular vesicles originating from autophagy mediate an antibody-resistant spread of classical swine fever virus in cell culture, Autophagy, 2021:1987673

3. Tao Wang, Yaru Liu, Ying Sun, Liang Zhang, Kangkang Guo*, Yanming Zhang*, Rab22a cooperates with Rab5 and NS4B in classical swine fever virus entry process, Veterinary Microbiology, 2022, 266:109363

4. Liang Zhang, Mingxing Jin, Mengzhao Song, Shanchuan Liu, Tao Wang, Kangkang Guo*, Yanming Zhang*, ARFGAP1 binds to classical swine fever virus NS5A protein and enhances CSFV replication in PK-15 cells, Veterinary Microbiology, 2021,255:109034

5. Kangkang Guo#, Xiuping Zhang#, Yufeng Hou#, Jing Liu, Quanwen Feng, Kai Wang, Lei Xu*, Yanming Zhang*, A novel PCV2 ORF5-interacting host factor YWHAB inhibits virus replication and alleviates PCV2-induced cellular response, Veterinary Microbiology,2020, 251:108893

6. Xiuping Zhang#, Xinxin Li#, Weihua Wang#, Jiali Qi, Dong Wang, Lei Xu, Yong Liu, Yanming Zhang, Kangkang Guo*, Diverse gene cassettes arrays prevail in commensal  Escherichia coli from intensive farming swine in four provinces of China, Frontiers in Microbiology, 2020,11:565349

7. Cheng Li, Yifan Wang, Hongqing Zheng, Wang Dong, Huifang Lv, Jihui Lin, Kangkang Guo*,Yanming Zhang*, Antiviral activity of ISG15 against classical swine fever virus replication in porcine alveolar macrophages via inhibition of autophagy by ISGylating BECN1, Veterinary Research, 2020,51(1):22

8. Liang Zhang, Tao Wang, Mengzhao Song, Mingxing Jin, Shanchuan Liu, Kangkang Guo*, Yanming Zhang*, Rab1b-GBF1-ARFs mediated intracellular trafficking is required for classical swine fever virus replication in swine umbilical vein endothelial cells, Veterinary Microbiology, 2020, 246:108743

9. Jiangman Lv#, Yanfen Jiang#, Quanwen Feng, Zhixin Fan, Ying Sun, Panpan Xu, Yufeng Hou, Xiuping Zhang, Yuxin Fan, Xingang Xu, Yanming Zhang*, Kangkang Guo*, Porcine Circovirus Type 2 ORF5 protein induces autophagy to promote viral replication via the PERK-eIF2a-ATF4 and mTOR-ERK1/2-AMPK signaling pathways in PK-15 cells, Frontiers in Microbiology, 2020, 11:320

10. Panpan Xu#, Shuangkai Jia#, Kai Wang, Zhixin Fan, Hongqing Zheng, Jiangman Lv, Yanfen Jiang, Yufeng Hou, Bihao Lou, Hongchao Zhou, Yanming Zhang*, Kangkang Guo*, MiR-140 inhibits classical swine fever virus replication by targeting Rab25 in swine umbilical vein endothelial cells, Virulence, 2020, 11(1):260-269

11. Liang Zhang, Di Zhao, Mingxing Jin, Mengzhao Song, Shanchuan Liu, Kangkang Guo*, Yanming Zhang*, Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells, Virulence, 2020, 11(1): 489-501

12. Ning Li, Jing Liu, Jiali Qi, Feng Hao, Lei Xu*, Kangkang Guo*. Genetic diversity and prevalence of porcine circovirus type 2 (PCV2) in China during 2000-2019, Frontiers in Veterinary Science, 2021, 8:788172

13. Kangkang Guo#, Lei Xu#, Mengmeng Wu#, Yufeng Hou, Yanfen Jiang, Jiangman Lv, Panpan Xu, Zhixin Fan, Ruiqi Zhang, Fushan Xing*, Yanming Zhang*, A host factor GPNMB restricts porcine circovirus type 2 (PCV2) replication and interacts with PCV2 ORF5 protein, Frontiers in Microbiology, 2019,9:3295

14. Yueling Ouyang#, Lei Xu#, Jiangman Lv, Yufeng Hou, Zhixin Fan, Panpan Xu, Yanfen Jiang, Mengmeng Wu, Ran Li, Yanming Zhang, Kangkang Guo*, Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages, Archives of Virology, 2019,164(5):1323-1334

15. Hongjie Cui, Wulong Liang, Dahui Wang, Kangkang Guo*, Yanming Zhang*, Establishment and characterization of an immortalized porcine oral mucosal epithelial cell line as a cytopathogenic model for porcine circovirus 2 infection, Frontiers in Cellular and Infection Microbiology, 2019, 9: 171

16. Kangkang Guo#, Haimin Li#, Xuechao Tan, Mengmeng Wu, Qizhuang Lv, Wei Liu, Yanming Zhang*, Molecular chaperone Jiv promotes the RNA replication of classical swine fever virus, Virus genes, 2017,53(3):426-433

17. Lv Qizhuang#, Guo Kangkang#, Zhang Guangfang, Zhang Yanming*, The ORF4 protein of porcine circovirus type 2 antagonizes apoptosis by stabilizing the concentration of ferritin heavy chain through physical interaction, Journal of general virology, 2016,97(7): 1636-1646

18. Ruiqiao Li#, Kangkang Guo#, Caihong Liu, Jing Wang, Dan Tan, Xueying Han, Chao Tang, Yanming Zhang and Jingyu Wang*. Strong inflammatory responses and apoptosis in the oviducts of egg-laying hens caused by genotype VIId Newcastle disease virus, BMC Veterinary Research, 2016, 12:255

19. Qizhuang Lv#, Kangkang Guo#, Han Xu, Tao Wang, Yanming Zhang*, Identification of putative ORF5 protein of Porcine circovirus type and function analysis of GFP-fused ORF5 protein, PLOS ONE, 2015,10(6):e0127859

20. Kang-kang Guo#, Qing-hai Tang#, Yan-ming Zhang*, Kai Kang and Lei He, Identification of two internal signal peptide sequences: critical for classical swine fever virus non-structural protein 2 to trans-localize to the endoplasmic reticulum, Virology Journal, 2011,8(236):1-7